Question: Can Aspirin And Clopidogrel Be Given Together?

Why is aspirin combined with clopidogrel?

The combination of clopidogrel and aspirin may lower the risk for major ischemic events among patients with minor ischemic stroke or high-risk transient ischemic attack compared with aspirin alone, according to results of the POINT study..

Which effect is produced on administration of aspirin with clopidogrel?

Aspirin and clopidogrel exert their antiplatelet effects by inhibiting thromboxane A2 production and adenosine diphosphate–induced platelet aggregation pathways, respectively. Aspirin has proven benefits in primary and secondary prevention of coronary artery disease.

What medications should not be taken with clopidogrel?

Clopidogrel may interact with other medicationsDiabetes drug. In most cases, repaglinide should not be taken with clopidogrel. … Stomach acid drugs (proton pump inhibitors) … Nonsteroidal anti-inflammatory drugs (NSAIDs) … Blood thinners.Drugs used to treat depression. … Salicylates (aspirin) … Opioids.

What painkillers can I take with clopidogrel?

Painkillers. It’s fine to take paracetamol with clopidogrel. You can also take opioid-type painkillers such as codeine, co-codamol, tramadol or morphine alongside clopidogrel.

When should you not take clopidogrel?

If you have certain health conditions such as a peptic ulcer or bleeding disorder you should not take clopidogrel, unless advised by a specialist. You should use clopidogrel with caution if you have liver or kidney problems. Clopidogrel must not be given to anyone under 16 years old, unless under specialist advice.

What is the best time to take clopidogrel?

You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.

Does clopidogrel affect blood pressure?

Arterial hypertension is associated with platelet activation, increased sCD40L levels and endothelial dysfunction suggesting that inhibition of platelet-derived sCD40L release may improve endothelial function and lower blood pressure (BP).

Can I take turmeric with clopidogrel?

Blood-thinning medications: Tumeric may make the effects of these drugs stronger, raising the risk of bleeding. Blood-thinners include warfarin (Coumadin), clopidogrel (Plavix), and aspirin, among others.

Can I drink coffee with clopidogrel?

Conclusions: Acute caffeine administration after clopidogrel loading appears to be associated with enhanced platelet inhibition 2 to 4 hours after clopidogrel intake. The mechanism probably involves synergistic increase in cAMP levels.

Is clopidogrel stronger than aspirin?

In summary, clopidogrel appears to be somewhat more effective than aspirin if one is willing to accept the unitary atherosclerosis paradigm. The gain, however, is modest: about 200 patients should use clopidogrel rather than aspirin for 1 year to prevent just one vascular event.

Is there a substitute for clopidogrel?

1). Besides oral anticoagulants, such as warfarin and the more recent dabigatran[9], and niche agents, such as cilostazol and ticlopidine[10,11], the most promising alternatives to clopidogrel in those with background aspirin therapy are prasugrel and ticagrelor.

Does clopidogrel cause joint pain?

Arthralgia and backache are also known to occur with its use. There have been case reports linking arthritis with the use of clopidogrel. We describe the case of a 64-year-old man who reported symptoms of fever and joint pains following initiation of therapy with clopidogrel. Acute-phase reactants were elevated.

How long does it take for clopidogrel to get out of your system?

by Drugs.com After a single, oral dose of 75 mg, Plavix (clopidogrel) has a half-life of approximately 6 hours. It takes 5.5 x half-life of a medicine for it to be out of one’s system, therefore Plavix should be eliminated from your system in 5.5 x 6 = 33 hours.

What is the difference between aspirin and clopidogrel?

Aspirin and Plavix (clopidogrel bisulfate) are drugs used to prevent blood clots. Aspirin and Plavix belong to different drug classes. Plavix is an anticoagulant and aspirin is a nonsteroidal anti-inflammatory drug (NSAID). Aspirin also is used to reduce fever, and to treat pain and inflammation in the body.

Can I take clopidogrel every other day?

Conclusions: Long term dual anti-platelet therapy with aspirin 81 mg daily and clopidogrel 75 mg every other day beyond 12 months after PCI with DES may be a safe and efficacious cost-saving strategy to prevent VLST.