- How is acute tubular necrosis diagnosed?
- What are the possible causes of acute tubular necrosis?
- How do you treat acute tubular necrosis?
- How long does it take to recover from acute tubular necrosis?
- What are the signs and symptoms of acute tubular necrosis?
- Can ATN reverse itself?
- Is acute tubular necrosis reversible?
- What drugs cause acute tubular necrosis?
- What are the three phases of acute tubular necrosis?
How is acute tubular necrosis diagnosed?
Acute tubular necrosis is usually diagnosed by a nephrologist (kidney specialist).
The diagnosis is mainly clinical but can be guided by microscopic examination of your urine.
A biopsy of the kidney tissue can be done in certain cases, especially when the diagnosis is uncertain..
What are the possible causes of acute tubular necrosis?
Acute tubular necrosis is kidney injury caused by damage to the kidney tubule cells (kidney cells that reabsorb fluid and minerals from urine as it forms). Common causes are low blood flow to the kidneys (such as caused by low blood pressure), drugs that damage the kidneys, and severe bodywide infections.
How do you treat acute tubular necrosis?
Generally, the treatment of choice for nephrotoxic ATN is to stop all nephrotoxic agents to prevent further damage to the kidney. Of note, calcium channel blockers may have some use in cyclosporine toxicity, as they may reduce the vasoconstrictive action of cyclosporine.
How long does it take to recover from acute tubular necrosis?
The majority of patients recover from ATN with the renal failure phase typically lasting 7-21 days. However, depending on the severity of the initial insult, time to renal recovery can often be prolonged and patients may require dialysis for months.
What are the signs and symptoms of acute tubular necrosis?
Symptoms of acute tubular necrosis include:A small amount of urine output.Swelling and fluid retention.Nausea and vomiting.Trouble waking up/drowsiness.Feeling sluggish.Confusion.
Can ATN reverse itself?
Because the tubular cells continually replace themselves, the overall prognosis for ATN is quite good if the underlying cause is corrected, and recovery is likely within 7 to 21 days.
Is acute tubular necrosis reversible?
ATN is a potentially reversible process, but patients with ATN requiring RRT often die before renal recovery as a result of the severity of the underlying illness or of lethal extra-renal complications of ATN.
What drugs cause acute tubular necrosis?
Drugs associated with tubular cell toxicity and acute in- terstitial nephropathy include aminoglycosides, ampho- tericin B, cisplatin, beta lactams, quinolones, rifampin, sulfonamides, vancomycin, acyclovir, and contrast agents (4,10,11).
What are the three phases of acute tubular necrosis?
The course of ATN can be divided into three phases:Onset or initiating phase. Lasting hours or days, this is the time from onset of the precipitating event (for example, toxin exposure) until tubular injury occurs.Maintenance phase. … Recovery phase.